Effects of fluticasone propionate in COPD patients with bronchial hyperresponsiveness

Effects of fluticasone propionate in COPD patients with bronchial hyperresponsiveness.

BACKGROUND Treatment of chronic obstructive pulmonary disease (COPD) with inhaled corticosteroids does not appear to be as effective as similar treatment of asthma. It seems that only certain subgroups of patients with COPD benefit from steroid treatment. A study was undertaken to examine whether inhaled fluticasone propionate (FP) had an effect on lung function and on indices of inflammation i...

Effects of fluticasone propionate in COPD patients

Comparison of fluticasone propionate and beclomethasone dipropionate on direct and indirect measurements of bronchial hyperresponsiveness in patients with stable asthma.

BACKGROUND Fluticasone propionate is a new inhaled corticosteroid with a 2:1 efficacy ratio compared with beclomethasone dipropionate with regard to lung function and symptom scores, without increased systemic activity. The aim of this study was to investigate whether this was also the case for bronchial hyperresponsiveness, assessed by both a direct (histamine) and an indirect (ultrasonically ...

Controlled short-term trial of fluticasone propionate in ventilator-dependent patients with COPD.

BACKGROUND There is no agreement about the efficacy of systemic corticosteroids in patients with COPD, but corticosteroids often are employed during exacerbations of the disease. The use of systemic or inhaled corticosteroids in patients in stable condition is even more controversial, even though the more severely affected patients seem to respond better. Unfortunately, in this subset of patien...

Salmeterol combined with fluticasone propionate improved COPD in patients during stable stage.

PURPOSE To evaluate the clinical effect of inhaled Salmeterol with Fluticasone propionate (50:500 μg) in patients with moderate to severe chronic obstructive pulmonary disease (COPD) during the stable stage of the disease. METHODS Sixty patients with moderate to severe COPD were randomly divided into trial and control groups (N=30 each). In the trial group, patients inhaled Salmeterol with Fl...